Journal article
Investigation of peripheral complement factors across stages of psychosis
L Laskaris, A Zalesky, CS Weickert, MA Di Biase, G Chana, BT Baune, C Bousman, B Nelson, P McGorry, I Everall, C Pantelis, V Cropley
Schizophrenia Research | ELSEVIER | Published : 2019
Abstract
The complement cascade has been proposed to contribute to the pathogenesis of schizophrenia. However, it remains unclear whether peripheral complement levels differ in cases compared to controls, change over the course of illness and whether they are associated with current symptomatology. This study aimed to: i) investigate whether peripheral complement protein levels are altered at different stages of illness, and ii) identify patterns among complement protein levels that predict clinical symptoms. Complement factors C1q, C3 and C4 were quantified in 183 participants [n = 83 Healthy Controls (HC), n = 10 Ultra-High Risk (UHR) for psychosis, n = 40 First Episode Psychosis (FEP), n = 50 Chro..
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Grants
Awarded by National Alliance for Research on Schizophrenia and Depression